杨胜祥，男，教授，浙江省高层次拔尖人才培养计划入选者，植物资源与创新药物化学课题组负责人。2011年获得化学生物学博士学位。2010年1月-2011年10月，在国家留学基金委建设高水平大学项目的支持下，赴德国哥廷根大学化学系完成联合培养博士生项目，师从国际著名天然药物化学家Hartmunt Laatsch教授从事抗肿瘤先导化合物的研究。2013年在德国哥廷根大学Petr Karlovsky教授课题组开展新型mycotoxins的全合成及其构效关系研究工作。2014年9月-2015年9月韩国建国大学特邀讲座教授交流一年。长期致力于有机化学和天然药物化学的教学和科研工作。杨胜祥老师主要从事天然药物/产物方向的研究，研究领域主要包括天然活性物质的发现及其功能产品的开发、功能分子的“垂钓”技术、计算机辅助药物设计以及新型植物激素独脚金内酯的化学生物学研究。近5年来，先后主持和参与国家重点研发项目、中央本级重大增减支项目、国家自然科学基金、浙江省“领雁计划”项目、浙江省自然科学基金及企业横向项目等多项课题；申请国家发明专利和实用新型专利20余项，授权发明专利5项，授权实用新型专利12项，发表SCI论文50余篇。
近五年的代表性论文：
[1]Chenggang Song, Xing Wang, Jian Yang, Yi Kuang, Yuxuan Wang,Shengxiang Yang*, Jianchun Qin, Lanping Guo. Antifungal biphenyl derivatives fromSorbus pohuashanensisLeaves infected byAlternaria tenuissiand their effect against crop pathogens. Chemistry & Biodiversity, 2021, doi: 10.1002/cbdv.202100079.(通讯作者)
[2]Chen Yu Chao, Kuang Yi,Yang Shengxiang*, Yuan Yuan, Huang Luqi. Synthesis of new halogenated GR24analogues and their evaluation as germinationpromotors onOrobanche Cumana.Frontiers in Plant Science, 2021,doi:10.3389/fpls.2021.725949.(通讯作者)
[3]Lin Li-Bin,Jian Xiao,Qiang Zhang, Rui Han,Biao Xu,Sheng-Xiang Yang*, Wen-Bo Han*, Jiang-Jiang Tang, and Jin-Ming Gao*.Eremophilane Sesquiterpenoids with Antibacterial and Anti-inflammatory Activities from the Endophytic Fungus Septoria rudbeckiae.Journal of Agricultural and Food Chemistry, 2021, doi:10.1021/acs.jafc.1c04131.(通讯作者)
[4]Qing-LinMou,Sheng-Xiang Yang,TingXiang,Wen-WenLiu,JianYang,Lan-PingGuo,Wen-JingWang,Xiao-LongYang.New cytochalasan alkaloids and cyclobutane dimer from an endophytic fungusCytospora chrysospermainHippophae rhamnoidesand their antimicrobial activities.Tetrahedron Letters, 2021, doi:10.1016/j.tetlet.2021.153207.
[5]Kuang Yi, Kirstin Scherlach, Christian Hertweck,Shengxiang Yang*, Diego Sampietro, Petr Karlovsky. Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides. Mycotoxin Research, 2021, submitted. (通讯作者)
[6] Kuang Yi, Xiating Shen, Huiyi Xu,Shengxiang Yang*, Jian Yang, Diego Sampietro. Optimization of ultrasound-assisted aqueous two-phase system extraction of β-carotene from sweet potato roots by response surface methodology. Journal of Food Science, 2021, submitted. (通讯作者)
[7]Sheng-Xiang Yang, Ming-Sheng Bai, Jian Yang, Yuan Yuan, Ya-Mei Zhang,Jian-Chun Qin, Yi Kuang, Diego A. Sampietro.Chemical composition and larvicidal activity of essential oils from
Peganum harmala,Nepeta catariaandPhellodendron amurenseagainstAedes aegypti(Diptera: Culicidae).Saudi Pharmaceutical Journal, 2020, 28: 560-564.
[8]Sheng-Xiang Yang, Cheng-Gang Song, Yi Kuang, Bing Liu, Yan-Xin Zhang,Ming-Zhe Zhang, Chun-Ying Zhang, Gang Ding,Jian-Chun Qin.Cytotoxicactivity ofinositolangelates andTirucallane-typealkaloids fromAmoora Dasyclada.Molecules,2020, 25:1222-1228.
[9]Juan Yang, Xu Han, Hao-Yu Wang, Jian Yang, Yi Kuang, Kai-Yue Ji, Yi Yang, Kai Pang,
Sheng-Xiang Yang*, Jian-Chun Qin, Hong-Peng Wang.Comparison of metabolomics ofDendrobium officinalein different habitats byUPLC-Q-TOF-MS.Biochemical Systematics and Ecology,2020,89:104007-104012.(通讯作者)
[10]Sheng-Xiang Yang, Bing Liu, Mei Tang, Jian Yang, Yi Kuang, Ming-Zhe Zhang, Chun-Ying Zhang, Chao-Yi Wang, Jian-Chun Qin, Lan-Ping Guo, Li-Chun Chao.Extraction of flavonoids fromCyclocarya paliurus(Juglandaceae) leaves using ethanol/salt aqueous two-phasesystem coupled with ultrasonic. Journal of Food Processing and Presevation,2020;00:e14469.
[11]Sheng-Xiang Yang, Jian-Zhong Sun, Jian Yang, Yuan Yuan, Jian-Chun Qin,D.A. Sampietro.
Herbicidal, fumigant and insecticidal potential of essential oil from flowers ofBuddleja alternifoliaMaxim.Allelopathy Journal, 2020,51: 113-124.
[12]Sheng-Xiang Yang, Jing-Fang Xiao, Ting-Kai Liu, Ze-Diao Huang,Xiang Li, Ye-Miao Chen,and Xiao-Long Yang.A 3D screening approach identifies the compoundepitajixanthone hydrate as a new inhibitor of cancer cellgrowth and invasion.Anti-Cancer Drugs, 2019,DOI: 10.1097/CAD.0000000000000873.
[13]Sheng-Xiang Yang,Wen-Ting Zhao, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen, Jian Yang, Xiao-Long Yang.Aureonitols A-B, Twonew C13-Polyketides fromChaetomium globosum, anEndophytic Fungus inSalvia miltiorrhiza.Chemistry & Biodiversity, 2019, 16:e1900364.
近五年主持的代表性科研项目：
[1]新型独脚金内酯类似物的合成及其对寄生植物种子生理的影响机制研究，中央本级重大增减支项目，100万，2020.9-2023.9，主持；
[2]中草药毒性药材的基原调查及中草药公共安全鉴定数据库，国家重点研发计划“科技基础资源调查”专项，110万，2019.1-2022.12，主持；
[3]植物内生真菌源氯代azaphilonoids类化合物的挖掘及其构效关系研究，浙江省公益研究计划项目，10万，2019.1-2021.12，主持；
[4]基于UPLC/Q-TOF-MS/MS技术对毛竹笋中新型植物内源激素独脚金内酯类物质的挖掘及其构效关系研究，浙江省竹资源与高效利用协同创新中心项目，6万，2018.12-2020.12，主持.
联系方式：浙江杭州临安武肃街666号浙江农林大学化学与材料工程学院
邮编：311300
邮箱：shengxiangyang2000@163.com
