赵伟 博士,中国药理学会会员,主要从事基于离子通道的天然产物活性物质筛选与药物安全性评价方面的研究。近年来,利用分子生物学与电生理学相结合的方法,我们建立了种类齐全的离子通道活性物质筛选平台。该平台涵盖了人的心血管、免疫、痛觉、肌肉、神经、脾、肺、肾脏等相关的离子通道细胞株及药物作用靶点的突变体。目前,我们已经利用该平台对上百种中药及其主要成分的活性进行了筛选和研究,在浙贝母、厚朴、五味子、和狼毒等传统中药中发现了丰富的离子通道活性物质。先后主持或者参与国家973计划,国家自然科学基金,浙江省基础公益项目及浙江农林大学科研发展基金等多项。截止2019年5月已发表论文13篇,其中SCI收录8篇。
论文和专利
1.Wei Zhao, Yuan Chen*. Progress in research of Kv1.1 and Kv1.3 channels as therapeutic targets. Current Topics in Medicinal Chemistry, 2016, 16(16): 1877-1885.
2.Jianwei Xu#, Wei Zhao#, Lanying Pan, Ailian Zhang, Qingmao Chen, Kai Xu, Haiyin Lu, Yuan Chen*, Peimine. a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia, 2016, 111: 1-6. (共同第一作者)
3.Jifeng Zheng#, Wei Zhao#, Kai Xu, Qingmao Chen, Yingying Chen, Yueliang Shen, Liping Xiao, Liqin Jiang*, Yuan Chen*. Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose. European Journal of Pharmacology, 2017, 800:23-33. (共同第一作者).
4.Liandi Kan#, Wei Zhao#, Lanying Pan, Jianwei Xu, Qingmao Chen, Kai Xu, Liping Xiao, Yuan Chen*. Peimine inhibits hERG potassium channels through the channel inactivation states. Biomedicine & Pharmacotherapy, 2017, 89:838-844. (共同第一作者)
5.Wei Zhao, Min Shi, Xiqian Ye, Fei Li, Xiaowei Wang, Xuexin Chen*. Comparative transcriptome analysis of venom glands from Cotesia vestalis and Diadromus collaris, two endoparasitoids of the host Plutella xylostella. Scientific Reports, 2017, 7:1298.
6.Wei Zhao, Min Shi, Xuexin Chen*. Immature morphology and development of Diadromus collaris (Hymenoptera: Ichneumonidae), an important endoparasitoid of Plutella xylostella (Lepidoptera: Plutellidae). Annals of the Entomological Society of America, 2014, 107(1): 234-241.
7.Zhizhi Wang, Min Shi, Wei Zhao, Qiaoli Bian, Gongyin Ye, Xuexin Chen*. Identification and characterization of defensin genes from the endoparasitoid wasp, Cotesia vestalis (Hymenoptera: Braconidae). Journal of Insect Physiology, 2013, 59(11): 1095-1103.
8.Yanyan Ren, Lanying Pan, Wei Zhao, Lei Xu, Jianwei Xu, Haiyin Lu, Yuan Chen*. Neochamaejasmin A inhibits Kv1.4 channel activity via direct binding to the pore. Brain Research, 2018 1683:17-26.
9.朱晓琳,陈渊,赵伟*,贝母素甲药理作用的研究进展,药物生物技术,2018,25(6):561-564. (通讯作者)
10.钟点,陈渊,赵伟*,雷公藤红素抗炎及免疫抑制的研究进展,药物生物技术,2018,25(1):64-69. (通讯作者)
11.张燕婷,陈渊,赵伟*,红霉素的心脏安全性研究进展,药物生物技术,2018,25(2):166-170. (通讯作者)
12.赵伟, 刘强*. 中国特有植物四合木(Tetraena mongolica)昆虫群落与多样性特征. 应用昆虫学报, 2010, 47(1): 177-182.
13.赵伟, 刘强*. 四合木(Tetraena mongolica)林地昆虫群落的组成、结构及多样性特征. 生态学杂志. 2011, 30(11): 2554-2561.
14.专利:陈学新,王知知,时敏,赵伟. 菜蛾盘绒茧蜂抗菌肽防御素基因、抗菌多肽及应用. 专利号:ZL 2012 1 0315023.2.
联系方式
邮箱:weizhao@zafu.edu.cn